Abstract Background Missed appointments are a common occurrence in primary care in the UK, yet little is known about the reasons for them, or the consequences of missing an appointment.This paper aims to determine the reasons for missed appointments and whether patients who miss an appointment subsequently consult their general practitioner (GP).Se
Summary: Unsatisfied kinetochore-microtubule attachment activates the spindle assembly checkpoint to inhibit the metaphase-anaphase transition.However, some cells eventually override mitotic arrest by mitotic slippage.Here, we show that 7896001020030 inactivation of TORC1 kinase elicits mitotic slippage in budding yeast and human cells.Yeast mitoti
Medulloblastoma (MB) is a highly heterogeneous and one of the most malignant pediatric brain tumors, comprising four subgroups: Sonic Hedgehog, Wingless, Group 3, and Group 4.Group 3 MB has the worst prognosis of all MBs.However, the molecular and cellular mechanisms driving the maintenance of malignancy are poorly understood.Here, we employed high